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CYP2E1 and ALDH enzymatic activity CYP2E1 activity was assessed by measuring the rate of oxidation of p -nitrophenol (PNP) to p -nitrocatechol as described 54

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Skin water content, transepidermal water loss (TEWL), skin elasticity, skin thickness, and the level of NMF constituents were determined in the SC at baseline and then at 12 weeks