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This shortening is a well-known biomarker of aging and is associated with increased risks of cancer, cardiovascular disease, neurodegeneration, and metabolic disorders Blackburn et al., Nature , 2006

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This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients

Orekhov AN, Orekhova VA, Nikiforov NG, Myasoedova VA, Grechko AV