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Thiamine hydrochloride (vitamin B1) in the formulation is known to cause life threatening anaphylaxis especially on multiple administrations if patient is allergic to it

These clinical benefits are thought to be mediated through its antioxidant, anti-inflammatory and mucolytic properties, its importance in detoxification processes, and potentially its ability to disrupt biofilms

Similarly, the ongoing effects of the hypertyrosinemia produced by the use of NTBC, as well as any associated complications with its use, including long-term behavioral and neuropsychological effects, remain to be better understood

[1] [4] There is insufficient evidence regarding the safety of glutathione injection in pregnancy and lactation, and its use in these populations should be avoided unless the potential benefits outweigh the risks