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Anything that meaningfully shifts perfusion pressure, blood viscosity, vascular regulation, or systemic hemodynamics could, in theory, intersect with risk in susceptible individuals

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Because a BMI basically of greater, 30 or greater does put you at risk of cardiovascular disease, of course diabetes, inflammation, I mean, all the things that can basically go wrong with your body, basically look at that BMI

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Understanding the potential mechanisms and distinguishing between medication-related tiredness and other causes is essential for appropriate management