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The clinical nuance: Routine baseline lipase/amylase is not universally mandated by guidelines, but is clinically reasonable particularly if a patient has a history of pancreatitis, cholelithiasis (gallstones), hypertriglyceridemia, or heavy alcohol use Symptom-triggered testing is the standard response: any severe, persistent upper abdominal pain radiating to the back during GLP-1 therapy should prompt immediate evaluation, not a scheduled lab appointment Ask your doctor: "Given my history, do you recommend a baseline lipase, and what symptoms should prompt me to seek immediate evaluation?" Question 6: What Will My Cholesterol and Lipid Panel Look Like on GLP-1s

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