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MOTS-Cs demonstrated effects on skeletal muscle metabolism and homeostasis make it a natural partner for Retatrutide in protocols where preserving lean mass is a priority

Notably, the glucose transporter-2 (GLUT2) has been implicated in glucose-stimulated GLP-1 secretion, as demonstrated by an impaired GLP-1 response to oral glucose in mice deficient for GLUT2, and this is accompanied by reduced glucose-stimulated insulin secretion and impaired glucose tolerance [272]

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doi: 10.1111/j.1398-9995.1990.tb00528.x

Many patients combine Epithalon with complementary peptides and metabolic therapies for synergistic effects on aging pathways