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1,6 Once stable, maintenance therapy can be decreased to an injection once every month or every other month

Wang J, Liu Y, Zhu C, Wang Z, Wang S, Fang S, Xu F

J Pharmacol Sci 108:227238 Massucci FA, DiNuzzo M, Giove F, Maraviglia B, Castillo IP, Marinari E, De Martino A (2013) Energy metabolism and glutamate-glutamine cycle in the brain: a stoichiometric modeling perspective

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In terms of natural products, similar iridoid components, such as -dihydroplumericin A isolated from frangipani and Neocornusides A isolated from calendula, all have the effect of treating diabetes