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The manufacturer recommends that patients using oral hormonal contraceptives switch to a non-oral contraceptive method, or add a barrier method of contraception for 4 weeks after tirzepatide initiation and for 4 weeks after each dose escalation

Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM

Once the pituitary releases growth hormone, it travels through the bloodstream and signals the liver to produce IGF-1 (Insulin-like Growth Factor-1)

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Thus, in modulating neutrophil activity, GLP-1RAs primarily exert indirect antitumor effects by reducing NET formation