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6.3 Critical assessment and challenges of SSP-targeted therapy 6.3.1 Target specificity and toxicity evaluation in normal tissues The SSP is not only aberrantly activated in tumor cells but also participates in fundamental metabolism in normal tissues, including the nervous system, immune cells and the liver

Once the tumor volume reached approximately 100 mm 3 , twelve mice were assigned at random (n = 3) and received the same treatment as previously described

B12 levels typically normalize once the root cause is addressed

These are known to help with melanin overproduction