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The dual targeting of immunometabolic pathways ( via SGLT-2Is/GLP-1RAs) and epigenetic regulators (e.g., miR-155) represents a paradigm shift in DM therapeutics

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While hyperthyroidism during pregnancy is often transient, occurring in 1-2 per 1000 pregnancies, pregnant women with hyperthyroid symptoms must be assessed and monitored carefully, as thyroid imbalances can cause developmental issues for the baby, and Graves disease must also be explored

Throughout the study period, subjects were directed to continue taking the same dose of any prescribed hypoglycemic agents unless hypoglycemia or severe complications occurred, in which case they were directed to reduce their dose immediately