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One to two refeed days per week at maintenance calories can improve long-term progress compared to continuous restriction

The combination of 2.4 mg/week cagrilintide with semaglutide led to the most significant weight loss (-17.1% from baseline), and both the 2.4 and 4.5 mg/week doses showed an identical placebo-adjusted weight reduction of -7.4% [10]

See the CagriSema comparison guide for detailed combination protocol information