(PubMed) Rajendran P, Kidane AI, Yu TW, et al
Biochim Biophys Acta 1146 : 229235 Aureli T, Miccheli A, Ricciolini R, Di Cocco ME, Ramacci MT, Angelucci L, Ghirardi O, Conti F
These partially processed toxins, aka intermediates, are even more dangerous free radicals than when they were in their original form, so need to be further processed in phases II and III
Lean mass loss was reported for patients on semaglutide (~10% loss relative to baseline) and tirzepatide (~11% loss relative to baseline) during Phase III clinical trials, STEP-1, NCT03548935 and SURMOUNT-1, NCT04184622, respectively 61, 62
It helps neutralize free radicals, protects cells from oxidative stress, and may contribute to reducing the effects associated with premature cellular aging