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Phosphinic peptides often share structural similarities with the transition-state of peptide substrate upon hydrolysis ( Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

Liposomal glutathione solves the glutathione supplementation issues by encapsulating active, preformed glutathione inside liposomes