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Numerous studies show a positive correlation between the level of TMAO concentration and the onset of several illnesses, including diabetes mellitus, hypertension, ischemic stroke, atrial fibrillation (AF), heart failure (HF), acute myocardial infarction (MI), and chronic kidney disease (CKD) [5]

The MTHFR gene variation may also be associated with lower levels of methionine, one of the amino acids needed for the bodys own synthesis of carnitine

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