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Research suggests that your bodys glutathione levels can drop significantly when you are sleep-deprived

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J Biol Chem 272:1701217017 Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K (2004) Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients

Rice D, Barone S (2000) Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models