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The main limitation of our meta-analysis is the small number of studies (together with small sample sizes) currently in the literature, with single studies only for the posterior cingulate cortex, the hippocampus, and the thalamus (none of which showed a difference in GSH levels between cases and controls)

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4 Anticancer mechanism of selenium Selenium primarily manifests its chemopreventive properties by ensuring proper redox equilibrium and preventing the accumulation of misfolded proteins, largely through the action of selenoproteins such as glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs), and selenoprotein P, which safeguard DNA from oxidative, mutagenic stresses (121)

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For a focused comparison between approved incretin-based options, see Tirzepatide vs Semaglutide