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Proton Pump Inhibitors and Bone Health: An Update Narrative Review

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It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)

Funding The authors are grateful for the support of NIH grants R01NS039587, R01NS086423 and R01HD102071

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