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At normal therapeutic doses (up to 3,0004,000 mg/day in adults), hepatic glutathione stores are typically adequate for NAPQI neutralization and rapid regeneration

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As IC/BPS might be multifactorial, future research should target different implicated pathways simultaneously and study the role of reactive oxygen species as a root cause in IC/BPS

Mitochondria are the main source of ROS in response to oxidants 7 , and play dominant roles in apoptosis 53,54,55,56,57,58 and necrosis in RPE cells 59,60

A more diluted solution can make this easier to measure accurately