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This is commonly referred to as neuronal firing. In contrast, influx of negatively charged ions can have inhibitory effects by hyperpolarizing the membrane and thus preventing neuronal firing (15)

Each capsule contains 300mg of ALA and 150mg of benfotiamine, and the recommended two-capsule daily dose mirrors whats used in many diabetic neuropathy trials

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Further in vitro studies have shown that IAA can promote epithelial cell proliferation and enhance tight junction repair by activating the AhR/IL-22 signaling pathway, thereby counteracting LPS-induced epithelial injury and preventing LPS-driven systemic inflammation 168