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When cortisol is elevated, the body can enter fight, flight or freeze mode, shutting down non-essential functions like digestion

It is essential to inform your GP or prescriber about all medications you are taking , including over-the-counter NSAIDs, to ensure your treatment plan is safe and appropriate for your specific circumstances

Kiessling S, Cermakian N (2017) The tumor circadian clock: a new target for cancer therapy

Apart from the above-mentioned statements, the other authors have no relevant financial or non-financial interests to disclose

Stakeholder Perspectives The information in this section is a summary of the input provided by the patient and clinician groups that responded to CADTHs call for input and from the clinical expert(s) consulted by CADTH for the purpose of this review