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Loss of muscle mass is a key driver of bone density decline, as it reduces the dynamic strain on the skeleton, thereby accelerating disuse signaling

Health and Well-Being Coaching Adjuvant to GLP-1 Induced Weight Loss

JAMA (2016) 316:500

[7] Effectiveness and Key Trials: The rapid uptake of GLP-1 receptor agonists is largely driven by their consistent and clinically meaningful benefits across multiple large randomized trials