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Description

This portfolio covered formulations, manufacturing processes, methods of use across the drugs 10+ approved indications, and dosing regimens

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In Phase 2 trials, retatrutide produced approximately 24% mean weight loss at 48 weeks at 12 mg, compared with about 22.5% for tirzepatide at 15 mg in the SURMOUNT-1 trial though direct head-to-head data is not yet available

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Carson JL, Carless PA, Hebert PC

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Most menstrual changes do not require treatment discontinuation but may benefit from dosing adjustment or slower titration

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