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In cell-culture studies, gene-expression and protein-synthesis changes are described over hours to a few days

In these reactions, activated c-Jun N-terminal kinase is involved in the deactivation of insulin receptor substrate-1 through phosphorylation

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Another theory is the opioid excess theory, which suggests that gluten and casein peptides are metabolized in the intestine into structurally similar short-chain peptides called gluteomorphins and casomorphins in the behavioral problems seen in these children [16]

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