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A 12-week study revealed that in sedentary participants, HMB not only maintained arm lean mass but also increased thigh muscle volume

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Additional preclinical and translational research has explored retatrutide in the context of metabolic and hepatic models, including studies of glucose handling and markers associated with steatotic liver phenotypes

Retatrutide is a once-weekly subcutaneous injection, but the specifics of administration can influence both efficacy and side effect management

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