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While all GLP-1RAs activate the same receptor, they differ in their structures (e.g., semaglutide has 94% homology to native GLP-1 with specific amino acid substitutions and fatty acid side chain allowing albumin binding) and half-life (~ 1 week for semaglutide, five days for dulaglutide, and 13 hours for liraglutide)
Any medication or substance that delays stomach emptying could potentially affect levothyroxine bioavailability, though clinical data on this specific pairing remains limited
The authors declare no additional competing interests
Last updated 1/6/2015
Whats especially concerning for these companies is the fact that a lot of the demand for their products comes from a relatively small number of customers, many of whom could be future users of GLP-1 drugs
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