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When a patient stops the medication, their body's natural hunger signals gradually return to their pre-treatment baseline

Unlike many existing peptides that target a single receptor, Retatrutide is a triple agonist

Clinicians treating obesity should screen for the presence of eating disorder psychopathology before prescribing GLP-1RAs, as these medications are contraindicated in cases of overweight or obesity associated with atypical anorexia nervosa, bulimia nervosa, and subthreshold bulimia nervosa

doi: 10.1002/ptr.6282

The weekly dosing frequency maintains steady levels of the medication in the body to suppress appetite, promote blood sugar control, and reduce body weight