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Compared with placebo or other interventions, GLP-1 receptor agonists use showed an association with an increased risk of overall thyroid disorders (RR 1.28, 95% CI 1.03-1.60)

Here we provide evidence that prolonged GLP-1R activation induces a robust metabolic adaptation in -cells

However, the decision to pursue semaglutide or any other weight loss method should be made based on individual needs and goals, taking into account medical advice from qualified professionals

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