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An increase in the nuclear translocation of CaMKIV/CREM decreases GPX4, which is accompanied by an increase in intracellular lipid-ROS, eventually leading to neutrophil iron apoptosis (170) ( Figure 3 )

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Eighty-five patients were randomly allocated to a control group (n = 42), which received western treatment alone, or an observation group (n = 43), which received integrated TCM and Western treatment

[3] Biosynthesis [edit] GGC is synthesized from L-glutamic acid and L-cysteine in the cytoplasm of virtually all cells in an adenosine triphosphate (ATP)-requiring reaction catalyzed by the enzyme glutamate-cysteine ligase (GCL, EC 6.3.2.2