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Rachel Brazil looks at the difficulties in making the peptides themselves, and whats coming next Its rare that the public becomes aware of a recently approved drug, but the chances are youve heard of semaglutide, or its tradename Ozempic, one of a growing number of drugs that replicates the action of the natural hormone, glucagon-like peptide-1

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Unlike many medications, GLP-1 drugs dont work in just one place

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That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant