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The concentration of 1 M was selected based on a previous in vitro study with ipamorelin 17 and upon previous studies in which the efficacy of ipamorelin was found to be similar to that of GHRP

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In the absence of structural information for the GLP-1R, the design of acid-containing ligands was driven by SAR and the observation that polarity was better tolerated in the benzimidazole (red) region (Fig