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Our previous study demonstrated that a 14-day daily administration of lenvatinib to rats reduced OCTN2 protein levels in the skeletal muscle and intestine, but not in the kidney, and consequently decreased L-carnitine content in the skeletal muscle (Jing et al., 2022)

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[4] [5] Patients experiencing symptoms potentially related to cortisol abnormalitiessuch as unexplained weight gain (particularly central obesity), persistent fatigue, muscle weakness, easy bruising, or mood changesshould undergo appropriate evaluation before attributing these to metabolic syndrome alone

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Like Semaglutide, Tirzepatide is a once-weekly injectable medication used for long-term weight management and blood sugar regulation