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Roberto Salvatori Division of Endocrinology and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, United States Contribution RS, Analysis and interpretation of data, Drafting or revising the article, Contributed unpublished essential data or reagents Competing interests The authors declare that no competing interests exist

Application frequency for topical protocols is typically once or twice daily, applied to cleansed skin at the target area

Ristow M, Zarse K, Oberbach A, Klting N, Birringer M, et al: Antioxidants prevent health-promoting effects of physical exercise in humans