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For example, its effects are partially reversed by naloxone, which suggests that it should be used with caution when combined with opioid medications

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While Ozempic focuses on hormonal signals and digestion, topiramate addresses appetite through brain chemistry, and combining them may increase the risk of side effects like dizziness, cognitive changes, or hypoglycemia

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This balance between size and specificity is frequently cited as a design achievement of the original Monash research program and is one reason the molecule has endured as a reference compound across multiple laboratories