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Mechanism of toxicity in rotenone models of Parkinson's disease

It is well established that iron overload and more generally ferroptosis can trigger macrophage polarization, increasing M1-like markers such as IL-6, IL-1, and TNF, while decreasing M2-like markers [25, 26]

929 TRPM2 deficiency alleviates I/R-induced liver dysfunction and cell ferroptosis in mice, and ferroptosis induced by TRPM2 is related to the up-regulation of ALOX12 expression caused by mitochondrial Ca 2+ accumulation