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The FDA label recommends supportive care rather than a specific antidote, and observational data on GLP-1 class medications show only about 6 percent of accidental exposures lead to serious outcomes

For levothyroxine, which is highly dependent on consistent absorption to maintain stable blood levels, a slower gastric transit time can mean more exposure to the absorptive surfaces of the gastrointestinal tract

It was originally developed to treat type 2 diabetes, because its designed to lower and stabilise blood sugar and helps the body to release insulin when its needed

While these agents are not recommended during pregnancy, their use in the preconception, periconception, and postpartum periods is increasing

However, as the futility boundary was crossed, there is enough data to exclude the association between GLP-1 agonists treatment and pancreatic cancer (considering a difference of 0.1% between treatment groups) (Fig