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Magi et al., 2021

The second patient (P2) diagnosed by trio-exome sequencing is compound heterozygous for c.225del

Structural insights into the quaternary catalytic mechanism of hexameric human quinolinate phosphoribosyltransferase, a key enzyme in de novo NAD biosynthesis

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Key benefits of MOTS-c include: Improved metabolic flexibility and insulin sensitivity Support for weight management and fat oxidation Potential anti-aging effects by reducing oxidative stress Enhanced endurance and muscle recovery in some studies