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The reaction is described as a nonimmune-mediated anaphylactoid reaction, with incidence of 3 per 10,000 treatments

Empirical evidence derived from preclinical investigations reveals substantial neuroprotective, adaptogenic, and mood-enhancing attributes, whereas emerging clinical research suggests significant enhancements in mood, resilience to stress, and overall psychological well-being

Plant Cell Rep 32(7):971983

It has been evaluated in multiple Phase 3 randomized controlled trials, meta-analyses, and a Cochrane systematic review across indications including Alzheimer's disease, vascular dementia, and stroke

Med (Berl.) 100 , 555568 (2022)