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Heat changes tendon biology, training load tolerance shifts, and overuse injuries to the Achilles, plantar fascia, and patellar tendon are well-documented [British Journal of Sports Medicine, 2019]

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When Ive looked at literature on methylene blue, Ive only found one case report of toxicity in humans

The 12mg weekly arm produced a 24.2% mean body weight reduction over 48 weeks, with 26% of participants achieving at least 30% total body weight loss a threshold previously unattained by any pharmacological intervention in a clinical trial setting