Although this review focused on the ability of gut-derived signals to control food intake, there is evidence that the gut and gut microbiota can also impact energy expenditure, although this requires more investigation 308,309,310
Levy, M
Other suggested mediating pathways by which semaglutide modifies immune system activity include reducing the proliferation of inflammatory cells [62], lowering the uptake of activated macrophages in blood vessels (resulting in fewer vascular injuries) [79], and reducing the development of atherosclerotic plaque lesions [66]
Likewise, the cardiovascular benefit of efpeglenatide was independent of GFR or the concomitant use of iSGLT-2, suggesting its additive and independent effect from the latter,85 as was also observed in the EXSCEL study.86 A recent meta-analysis of the 8 published cardiovascular safety clinical trials, and which included a total of 60
It is therefore far outside the potentially hazardous range, is absolutely safe and meets the highest quality standards
