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Statements Author contributions KC: Conceptualization, Visualization, Writing original draft, Writing review & editing

As tcnicas manuais de aplicao so realizadas por via parenteral, sendo as mais utilizadas na intradermoterapia ou mesoterapia a intradrmica, subcutnea e intramuscular, lembrando que a aplicao intramuscular no considerada uma tcnica mesoterpica, uma vez que Pistor relata que a tcnica consiste em injees intradrmicas ou subcutneas de um frmaco ou de uma mistura de vrios produtos denominado, melnge ou mesclas