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Lilly's Phase 2 Retatrutide Results Published in The New England Journal of Medicine Show the Investigational Molecule Achieved up to 17.5% Mean Weight Reduction at 24 Weeks in Adults with Obesity and Overweight

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As expected, the total intracellular -GC and GSH pools were significantly decreased in cells expressing shACTL6A (Supplementary Fig 4a, b)

For oxygen consumption measurement, the mitochondria were resuspended in MiR05 medium (0.5 mM EGTA, 3 mM MgCl 2 , 60 mM lactobionic acid, 20 mM taurine, 10 mM KH 2 PO 4 , 20 mM HEPES, 110 mM Sucrose, 0.1% BSA, adjusted to pH 7.1 with KOH)

10.1016/j.brainres.2018.08.022 91 WangY.LimK.NormandinM.ZhaoX.ClineG