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Conclusion Our findings highlight multiple mechanisms by which metformin-induced formation of reactive oxygen species may contribute to its efficacy in prostate cancer treatment, including promotion of oxidative stress, Nrf2 activation, and modulation of redox-related pathways, leading to its anti-survival action

Who This Combined Protocol May Apply To and Provider Decision Framework A combined glutathione-tirzepatide approach may be considered in patients with documented oxidative stress or inflammatory burden, concurrent metabolic syndrome, and clear need for weight loss or glycemic control

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