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Dosing a short-acting GHRH analog (sermorelin, no-DAC CJC) at bedtime stacks the peptides pulse on top of the natural one, amplifying it rather than fighting it

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This absence of IGF-1 stimulation is critical for appetite neutrality because IGF-1 has known effects on hypothalamic neuropeptide expression, including alterations to neuropeptide Y (NPY) and agouti-related peptide (AgRP), both potent appetite stimulators