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Patients with simple steatosis and no additional risk factors may require testing only if symptoms develop, whilst those with advanced liver disease or on medications affecting B12 absorption might benefit from periodic monitoring as advised by their GP or specialist

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By constructing humanized animal models to modify the host, such as transplanting human hematopoietic stem cells or human liver cells into immunodeficient mice to carry functional human immune cells or target organs, the interaction between engineered bacteria and human cells can be evaluated in a living environment