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Direct injection of 1 nmol GLP-1, exendin-4, or liraglutide to the ARC significantly suppressed food intake and body weight, with the effects observed over the 24 hours following injection [71,79,80]

The best way to get over a plateau is to again significantly alter the energy balance, which can be done via increased physical activity or further decreasing food intake, for example, he said

Whether the superior outcomes compared to earlier compounds are attributable to the glucagon receptor component, differences in dose optimisation, or patient selection factors remains an active area of mechanistic investigation

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