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One of the strengths of our analysis is that we restrict our population of study to patients who report adverse effects of GLP-1 agonists, and only vary the cumulative dose at which adverse events are reported

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Although the findings in the CANVAS trial showed a higher risk of amputation when taking canafliglozin compared to placebo [92], no significant difference in the risk of this complication was observed in the CREDENCE study [88]

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