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While our sensitivity analysis suggests lower risks and a lower number of preventable CVD events from using laboratory-based equations incorporating total and HDL-cholesterol changes instead of BMI changes, it is possible that treatment for hypercholesterolemia in a number of subjects (17% were estimated to be on cholesterol-lowering medication) may have resulted in lower cholesterol levels and underestimated risks

On average, they continued to lose weight, though at a slower rate than initially

Thats important for people who cant absorb B12 naturally through food or oral pills

This limitation has been addressed by increasing serum UA in various ways, both pharmacological and genetic, including knockout of the uricase gene

Marrosu F, Maleci A, Cocco E, Puligheddu M, Barberini L, Marrosu MG