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In contrast, GLP-1RAs enhance incretin signaling, increasing glucose-dependent insulin secretion, suppressing glucagon, delaying gastric emptying, and promoting satiety [20]

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10.1038/33416 117 KitamuraY.IndenM.MiyamuraA.KakimuraJ.-I.TaniguchiT.ShimohamaS

Perhaps most concerning: if patients stop taking the medication, much of the weight and associated health risks often return