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thaliana by cauliflower mosaic virus (CaMV), systemic induction of GST1 was associated with increased virus titers and the development of disease symptoms (Love et al., 2005)
BCR-ABL encodes a constitutively active tyrosine kinase that phosphorylates a panel of downstream targets to cause uncontrolled cell proliferation, protein synthesis, and anti-apoptotic signals 3,4,5,6
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
Furthermore, given that we have demonstrated that this mitochondrial adaptation is to promote rebalancing of pyrimidine levels, mitochondrial biogenesis could also be used to identify patient cohorts likely to benefit from UCK2 inhibitor combinations