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If weight loss alone doesn't explain the benefit, inflammation may play an important role

It is a systemic intervention that happens to have effects in the exact pathways that drive migraine

Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]

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